Endocrine System >
Primary Hyperaldosteronism

“Tumour causing increased aldosterone production”

Pathophysiology
  1. Conns Tumour
  2. Increased aldosterone production
  3. Decreased potassium retention as well as increased sodium retention
Clinical Presentation
  • Hypokalemia
    • Muscle weakness
    • Constipation
  • Hypernatremia
  • Hypertension
    • Headaches
  • Metabolic alkalosis
Investigations
  • Aldosterone to renin ratio:
    • Primary: should show high aldosterone and low renin
    • Secondary: high aldosterone and renin
  • Abdominal CT and adrenal vein sampling to differentiate bilateral sources of aldosterone excess
Management
  • K+ sparing diuretics
  • Removing tumour in Conns syndrome
  • Treat hypertension
  • Treat metabolic factors
Complications
  • Complications related to hypertension
    • HF
    • Stroke
    • Kidney failure
  • Complications related to hypokalemia
    • Weakness
    • Arrhythmia
    • Thirst
    • Muscle cramps

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