Neurology >
Guillain Barré Syndrome

“Progressive weakness of proximal muscles due to Antibodies against the myelin sheath”

Risk Factors
  • Infection (usually campylobacter jejuni)
Pathophysiology
  1. Infection
  2. The body produces Antibodies against the myelin sheath
  3. progressive weakness of proximal muscles
Clinical Presentation
  • Can get flaccid paralysis
  • Often 4 limbs affected
  • “Ascending” paralysis (first legs than arms) but proximal muscles before distal
  • Can often present first with back pain
  • Areflexia
  • Cranial nerve involvement eg diplopia
Investigations
  • Lumbar puncture
    • High protein but normal WBC
  • Nerve conduction studies
Management
  • IV immunoglobulins
  • Steroids not useful
Complications
  • Breathing difficulties
  • Hypertension
  • Residual numbness
  • Bladder function problems

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